antiarrytmiska arylkondenserade och hetarylkondenserade 2,4 - diazepin - och 2,4 - diazocinderivat och deras framstaellning.

摘要

Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II CHEM delta -aminoamides of formula III and aryldimethanamines of formula XXXVII CHEM wherein A is an aryl, alicyclic or or hetaryl ring; R1 is hydrogen, alkyl, aryl or hetaryl; R2 is hydrogen, alkyl, substituted alkyl, or aryl; R3 is hydrogen, alkyl, aryl, aralkyl, hetaryl or heteroatom substituted alkyl or aralkyl; R4 is hydrogen, alkyl or substituted alkyl; R5 is hydrogen, alkyl, aryl or hetaryl; R6 is hydrogen, alkyl, alkoxy, nitro, alkylsulfonamido, halogen or a fused benzene ring; R9 is hydrogen, alkyl, substituted alkyl or aralkyl; and R10 is hydrogen, alkyl, substituted alkyl, aryl or hetaryl. This invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulae XXXVI, XXX, II, III, and XXXVII.