(S)-ALKYL 3-(THIEN-2-YLTHIO)BUTYRATE AND ANALOGS AND SYNTHESIS THEREOF

摘要

284/WHN23 17837 TITLE OF THE INVENTION (S)-ALKYL 3-(THIEN-2-YLTHIO)BUTYRATE AND ANALOGS AND SYNTHESIS THEREOF (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno¢2,3-b!thiopyran-2-sulfonamide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma.