1-oxa-2-oxo-3,8-diazaspiro4,5decane derivatives, pharmaceutical compositions containing them and processes for preparing them

摘要

This invention relates to 2-oxo-3,8-diazasplro[4,5]-decane derivatives of the formula (I), whereinR represents hydrogen or a alkyl or cycloalkyl ,or carbocyclic aryl or-carbocyclic aryl-alkyl optionally substituted on the aromatic ring by one or more halogen atoms, alkyl or alkoxy ;one of R¹ and R² represents hydroxyl whilst the other represents methyl ;Ph¹ and Ph², which may be the same or different, each represent phenyl unsubstituted or substitued by one or more halogen atoms or alkyl, alkoxy, trihalomethyl or hydroxyl optionally esterified by an alkanoic acid; andn is 1 or 2;and optical isomers and mixtures thereof, and all solvates, hydrates, acid addition and quaternary ammonium salts thereof, to pharmaceutical compositions containing these compounds and processes for their preparation.;The compounds of formula (I) exert antihypoxic effects in the central nervous system and therefore, they appear useful for the prevention and treatment of distubances of the cognitive functions as well as mania, agitation, psychomotor disquiet, senile and multiinfarctual dementia and Alzheimer's disease.