NEW SUBSTITUTED DERIVATIVES IN 15 OF 20, 21-DINOREBURNAMENINE, PROCESS FOR THEIR PREPARATION AND THE NEW INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS DRUGS AND THE COMPOSITIONS COMPRISING THEM.

摘要

The products of formula (I): BR/ (CF DRAWING IN BOPI) BR/ BR/ in which X1, X2 and X3, identical or different, represent a hydrogen atom, a halogen atom , an alkyl, alkenyl or alkynyl radical containing at most 18 carbon atoms and optionally substituted, an alkyloxy radical containing at most 7 carbon atoms optionally substituted, a hydroxy, trifluoromethyl or nitro radical, an amino, mono or dialkylamino radical, or an optionally substituted phenyl radical, BR/ (CF DRAWING IN BOPI) BR/ BR/ (CF DRAWING IN BOPI) BR/ BR/ in which R represents: BR/ a) a alkyl, alkenyl or alkynyl radical containing at most 7 carbon atoms and optionally substituted, BR/ b) an optionally substituted phenyl radical, BR/ (CF DRAWING IN BOPI) BR/ BR/ in which R1 represents one of the two groups BR/ (CF DRAWING IN BOPI) BR/ BR/ in which one of the radicals R8 or R9 represents a hydrogen atom ene, an alkyl, alkenyl or alkynyl radical containing at most 6 carbon atoms and optionally substituted, a phenyl radical optionally substituted, an esterified carboxy radical, a cyano radical or an acyl radical having from 2 to 6 carbon atoms, BR / and the other of the radicals R8 or R9 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical containing at most 6 carbon atoms and optionally substituted or a phenyl radical optionally substituted, BR/ and R10 represents an atom hydrogen, an alkyl, alkenyl or alkynyl radical containing at most 5 carbon atoms, and optionally substituted, or an optionally substituted phenyl radical. BR/ These products have interesting pharmacological properties which justify their use as medicines.