NOVEL SUBSTITUTED 20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE NEW INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

摘要

The invention relates to new substituted derivatives of 20,21-dinoreburnamine, their preparation process and the new intermediates thus obtained, their application as medicaments and the pharmaceutical compositions containing them. /P P The invention relates to new compounds of formula I: BR/ (CF DRAWING IN BOPI) BR/ in which R1, R2 and R3, identical or different, represent a hydrogen atom, a halogen atom, an alkyl radical or alkoxy containing from 1 to 5 carbon atoms, a hydroxy, trifluoromethyl or nitro radical, R1, R2 and R3 which cannot simultaneously represent a hydrogen atom and in which the group: represents either:, or:, or either: the said products of formula I being in all the possible isomeric forms racemic or optically active as well as the addition salts with mineral or organic acids of said products of formula I.