Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contain at least 40 % serine residues and preferably have the formula (Ser, Ser, Ser, Ser, Gly)y where y is » 1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.
展开▼
