process for the production of 1 - phenyl - 2 - diethyl - aminocarbonyl 2 phthalimidomethyl - cyclopropan.

摘要

Process for the preparation of (Z)-1-phenyl-1-diethylaminocarbonyl- 2-phthalimidomethylcyclopropane. …??This process is characterised by the use of the following successive reactions: - opening of 1-phenyl-2-oxo-3-oxabicyclo[3.1.0]hexane with diethylamine with the aid of a Lewis acid-amine complex;… - the (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane thus obtained is converted into a chlorine derivative by the action of a reactant such as thionyl chloride;… - the (Z)-1-phenyl-1-diethylaminocarbonyl-2-chloromethylcyclopropane thus obtained is treated with a phthalimide salt in an organic solvent to obtain (Z)-1-phenyl-1-diethylaminocarbonyl-2- phthalimidomethylcyclopropane.