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Method for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material
Method for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material
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机译:测定生物材料中药物,内源性或其他化学物质的少量物质的方法
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摘要
The invention relates to a process for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material, characterized by either binding the compound to be determined and its deuterated analog to an antibody present in excess, which antibody is coupled to a stationary phase of a polymeric material, and separating the two compounds from the antibody and measuring by mass spectrometry the proportion of deuterated compound/not deuterated compound or, respectively, cross-reacting compound; or, in case a suitable deuterated or cross-reacting compound is not available, utilizing as the internal standard also a chemically similar compound which, however, is added after the antibody-mediated extraction, and inserting a separating process before mass spectrometry.
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