2-oxo-3,8-diazaspiro(4,5)decane derivatives, pharmaceutical compositions containing them and process for preparing same

摘要

The invention relates to, therapeutically active 2-oxo-3,8- diazaspiro[4,5]decane derivatives (I), ##STR1## wherein R means hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two optionally being substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);PPone of R.sup.1 and R.sup.2 stands for a hydroxyl group whereas the other means a methyl gorup;PPR. sup.3 and R.sup.4, which are the same or different, represent hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl group or a hydroxyl group optionally esterified by a C.sub.1-4 alkanoic acid; andPPn is 1 or 2,PPtheir isomers, solvates, hydrates, acid addition and quaternary ammonium salts.