HYDROXAMINE ACID DERIVATIVES AND THOSE OF N-HYDROXI-UREA, PHARMACEUTICAL PREPARATIVES CONTAINING THEM AS ACTIVE SUBSTANCE AS WELL AS METHODS FOR PRODUCING SAID COMPOUNDS AND PREPARATIVES

摘要

Certain novel hydroxamic acid and hydroxyurea derivatives having structure (I), wherein R1 is hydrogen, alkyl, alkenyl, amino or substituted amino, R4 is hydrogen, a pharmaceutically acceptable cation, aroyl or alkoyl, A is alkylene or alkenylene, X is oxygen or sulfur, each Y is hydrogen, halo, cyano, hydroxy, alkyl, alkoxy, alkylthio, alkenyl, alkoxyalkyl, cycloalkyl, aryl, aryloxy, arylalkyl, arylalkenyl, arylalkoxy or substituted aryl, Z is oxygen or sulfur, m is 0 or 1, n is 1 to 5 and p is 2 to 6 inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.