3-ACYL-5,6-DIHYDRO-4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-6-ONES AND RELATED COMPOUNDS,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

摘要

A compound selected from the group consisting a compound of the formula IMAGE I wherein R1 is selected from the group consisting of phenyl, cycloalkyl of 4 to 6 carbon atoms and IMAGE R4 and R5 are individually hydrogen or alkyl of 1 to 5 carbon atoms, R6 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, phenyl, halogen, alkoxycarbonyl of 2 to 5 carbon atoms, cyano, amido and mono- and dialkylamido of 1 to 5 alkyl carbon atoms, R2 and R3 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and cycloalkyl of 3 to 5 carbon atoms or taken together form alkylene of 3 to 5 carbon atoms, X and Y are individually selected form the group consisting of hydrogen, halogen, -NO2, azido, -CN, -CF3 and alkyl and alkoxy of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts capable of inducing an affinity for benzodiazepine receptors and a novel process and novel intermediates for their preparation.