PROCESS FOR PREPARING HALOALKYL THIAZOLES AND SOME SUCH NOVEL HALOALKYL THIAZOLES

摘要

A process for the preparation of a compound of the formula CHEM wherein R1 is hydrogen or (C1-C4)alkyl, X is chloro or bromo and A represents a 6 membered carbocylic aromatic or a 5 or 6 membered heterocyclic ring which is optionally substituted by one of iodo or trifluoromethylthio, or one or two of fluoro, chloro, bromo, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkylthio, (C1-C4)alkylsulfinyl, (C1-C4)alkylsulfonyl, or trifluoromethyl, comprising reacting haloacetonitrile with a compound of the formula CHEM wherein A is as defined above or a hydrohalide salt thereof. The compounds of the formula (I) are useful intermediates in the preparation of heterocyclic oxophthalazinyl acetic acids having aldose reductase inhibitory activity. Some of the compounds of the formula (I) are novel, and these also form a part of the invention.