ENANTIOSELECTIVE PROCESS FOR PRODUCING 1-.BETA.-METHYLCARBAPENEM ANTIBIOTIC INTERMEDIATES

摘要

3326P/0716A3327P/l006A17179YTITLE OF THE INVENTIONENANTIOSELECTIVE PROCESS FOR PRODUCINGl-BETA-METHYLCARBAPENEM ANTIBIOTIC INTERMEDIATESABSTRACT OF THE DISCLOSUREA process is described for the stereo-controlled synthesis of intermediates useful inproducing l-betamethylcarbapenem antibioticAn example of a compound prepared by the processof the present invention, would be a compound ofFormula II:(II)wherein X1 and X2 are independently O or S, R1 isC1-C4 lower alkyl or alkoxyl, R2 and R9 areindependently selected from hydrogen, C1-C4 linear,branched or cyclic alkyl, unsubstituted or substitutedwith fluoro, hydroxy, or protected hydroxy, with theproviso that both R2 and R9 are not unsubstitutedalkyl, R3 is H or easily removable protecting group,R4, R5 and R6 are independently selected from H,C1-C4 alkyl, C7-C10 aralkyl, C6-C10 aryl,C7-C10 alkaryl, whlch can be substituted with -OH,-OR10, -SH, -SR10, where R10 is C1-C4 alkyl,with the proviso that R4 and R5 are not identical.