SUBSTITUTED 3,4-DIHYDRONAPHTHALENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS AND COMPOSITIONS

摘要

Substituted 3,4-dihydronaphthalenes of the formula I wherein R1 is the methyl or the amino group, R2 represents a hydrogen atom or the methyl group and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, the allyl or the crotyl residue or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III and introducing the residue -CO-R1.