PLATELET GPIIIa P1?A1 AND P1A2¿ EPITOPES, THEIR PREPARATION AND USE

摘要

Polypeptides and fusion polypeptides that immunologically mimic the native P1?A1 and P1A2¿ determinants of platelet protein GPIIIa are disclosed. Also disclosed are DNA segments and recombinant DNA molecules that encode those polypeptides and fusion polypeptides and methods for expressing and using those determinants. Antibodies that immunoreact with one determinant or the other, but not both are also disclosed, as are methods of preparing and using those antibodies.