Use of peptide derivatives for the manufacture of endopeptidase inhibiting drugs 24.15 and 24.16.

摘要

The invention relates to the use of peptide derivatives for the manufacture of endopeptidase inhibiting drugs 24.15 and 24.16. BR/ These peptide derivatives have the formula: BR/ (CF DRAWING IN BOPI) BR/ BR/ in which R1 is an optionally substituted aryl or aralkyl group, R2 is Pro, Hyp, thiazolidine or dehydroproline, R3 is H or an alkyl radical, R4 is an alkyl group or the side chain of an amino acid, R5 and R6 may be H, NH4 + or metals. By way of example, N- (phenylethylphosphonyl) -Gly-Pro-aminohexanoic acid has an inhibition constant of 0.9nM vis-à-vis the endopeptidase 24.16. / P