Use of peptide derivatives for the manufacture of products that inhibit endopeptidases 24.15 and 24.16.

摘要

The invention relates to the use of peptide derivatives for the manufacture of medicaments inhibiting endopeptidases 24.15 and 24.16. These peptide derivatives correspond to the formula: IMAGE in which r1 is an optionally substituted aralkyl group, R2 is Pro, Hyp, thiazolidine or dehydroproline, R3 is H or an alkyl radical, R4 is an alkyl group or the side chain of an amino acid, R5 and R6 can be H, NH4+ or metals, and R7 is H or CH3. N-(Phenylethylphosphonyl)-Gly-Pro-aminohexanoic acid and N-(phenylethylphosphonyl)-Ala-Pro-aminohexanoic acid are examples of efficient derivatives.