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Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
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机译:抑制von Willebrand因子与血小板SPIB受体结合的肽
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摘要
This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from synthetic peptide mixtures or isolated from lysates of organisms capable of producing recombinant human vWF. The fragments and sub-fragments are useful in the prevention and treatment of cardiovascular disorders by virtue of their ability to inhibit the binding of vWF to platelets, heparin and/or collagen.
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