New chemical compound and its manufacturing method and the application null which possess the pepuchida - ze

摘要

NEW MATERIAL:A compound of formula I (n is integer of 1 or more; R1 is 5-25C-saturated or unsaturated straight-chain hydrocarbon group; R3 is lower alkyl ester, hydroxymethyl, formyl; R2 is methyl, phenyl, indolyl, amino, hydroxy, methylthio; R5 is H, or when n is 3, R2 incorporates to R5 to represent the single bond between C and N atoms). USE:Antiamnesic. PREPARATION:The reaction of a carboxylic acid of formula II, its anhydride or chloride with the peptide of formula III, which has lower alkyl-esterified carboxyl groups and contains proline residues, gives the compound of formula I.