Possess puroriruendopepuchida - ze inhibition activity chemical compound and its medicine application

摘要

A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein: R represents hydrogen or acyl; U represents -O-, -CHR1- or -NR2-, wherein R1 represents hydrogen or heterocycle, and R2 represents hydrogen or lower alkyl substituted by lower alkoxycarbonyl; V represents -O-, -S-, -CHR3- or -NR4-, wherein R3 represents hydrogen or lower alkoxycarbonyl, and R4 represents hydrogen, lower alkyl or acyl; W represents methyl, heterocycle or optionally substituted phenyl; X and Y, which may be the same or different from each other, represent each -CH¿2?- or -S-; m represents an integer of 0 to 6; and n represents an integer of 1 to 4. The compound has a specifically potent inhibitory activity against prolyl endopeptidase and suppresses the decomposition and deactivation of TRH, substance P, neurotensin, vasopressin, and so forth. Hence it can be used for preventing and/or treating dementia and amnesia including Alzheimer's disease.