ETHYNYLHETEROAROMATIC ACIDS HAVING RETINOIC ACID-LIKE ACTIVITY

摘要

ABSTRACTRetinoid-like activity is exhibited by compounds ofthe formulawherein A is pyridyl, furyl, thienyl, pyridazinyl,pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH andits esters, amides and pharmaceutically acceptable salts,-CHO and its acetal derivatives, -COR1 and its ketalderivatives where R1 is -(CH2)nCH3 where n isdefined above, or -CH2OH and its ether and acyl esterderivatives; or a pharmaceutically acceptable salt.