HYDROXAMATE AND HYDRAZIDE DERIVATIVES OF POLYAMINES AND THEIR MEDICAL USE AS CHELATING AGENTS

摘要

The invention relates to a compound of formula (I) A [X (CR1R2) n] MXA, a chelate complex or salt thereof used as a therapeutic or diagnostic agent. In said formula (I) each of R1 and R2 can independently be a hydrogen atom or an alkyl or alkoxy group optionally carrying one or more substituents selected from hydroxy, alkoxy and aryl; each X independently represents an oxygen or sulfur atom or a group NA; each A independently represents a hydrogen atom or an alkyl group optionally substituted by a group Y; each Y represents a hydrogen atom or a group Z, COZ, SO3R6, CSZ, PO2Z or B; or one or more pairs of A groups in various moieties X may together form a group [(CR1R2) NX1] p (CR1R2) n, or a group A in a nitrogen intermediate chain can be a group [(CR1R2) NX1] p (CR1R2) nX1A, wherein p represents an integer between 0 and 6, and each X1 independently represents an oxygen or sulfur atom or a group NA1, wherein A1 has the same meaning as a, but not part of a group attached to more than one nitrogen atom; or two R 1 and / or A adjacent groups may together form a homo or heterocyclic ring, saturated or unsaturated 5 to 7 membered, containing 0, 1 or 2 ring heteroatoms selected from oxygen, nitrogen and sulfur; m represents an integer between 2 and 8; n represents an integer between 2 and 4.