N-acylate derivatives of anti-ulcerative omeprazole, its preparation method, and its preparation method using omeprazole

摘要

The present invention relates to an N-acylate derivative (I) of omeprazole, a process for preparing the same, and a process for preparing omeprazole used as a therapeutic agent for ulcers using the same. I);(Wherein, " R " represents a functional group selected from a hydrogen atom, methyl, chloromethyl, trichloromethyl, bromomethyl, phenylmethyl or phenoxymethyl);Reacting 2-chloromethyl-3,5-dimethyl-4-methoxypyridine (II) with N-acyl-5-methoxy-2-mercaptobenzimidazole (III) to obtain thioether , And oxidizing the thioether (IV).;When the omeprazole is prepared by using the process for producing the N-acylate derivative (I) of the present invention, there is no by-product as in the case of reacting chloromethylpyridine with N-acylbenzimidazole, Which is easily separated, and a high purity compound can be produced by using the hydrolysis method using an enzyme.