Method and apparatus for manufacturing a transdermal therapeutic system for the administration of active substances to the skin in the form of a sheet-like a multi-chamber - or multichamber-channel system

摘要

PCT No. PCT/EP94/01278 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Apr. 25, 1994 PCT Pub. No. WO94/26346 PCT Pub. Date Nov. 24, 1994In a process for the production of a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system an active substance-containing layer is introduced between top layer and bottom layer; subsequently top and bottom layer are squeezed at individual and/or coherent sites under displacement of the intermediary sites of the active substance-containing layer and formation of active substance-containing chambers or channels, and at the same time or after that top layer and bottom layer are bonded permanently at the squeezed places.