A process for the preparation of a concentrate of the factor viii - of von willebrand - factor - complex of the blood coagulation of fully plasma.

摘要

The invention relates to a process for the preparation of a concentrate of complex factor viii inhibitors - von willebrand factor at a high specific activity on the basis of total plasma cryoprecipitate (,). br / the method comprises a prepurification involving a double treatment with the barium chloride and the aluminum hydroxide (br / the method then comprises a purification by chromatography on anion exchange resin, deae - fractogel. & br / the method comprises a viral inactivation step by a treatment with the solvent detergent -. & br / the method also makes it possible to recover the fibrinogen, albumin, immunoglobulins, antithrombin iii and fibronectin, from the same plasma. & br / the different concentrates obtained by the process of the invention are intended especially for therapeutic use.