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BILE ACID-ADSORBING AGENT

机译:胆汁酸吸附剂

摘要

PURPOSE: To prepare a bile acid-adsorbing agent containing an ion exchange resin comprising a specific cross-linked polymer, sufficient in small dosages, lowered in foreign feeling on its oral administration, having high stability against acids, and useful as a hyperlipidemia-treating medicine capable of lowering a cholesterol value in blood. ;CONSTITUTION: The agent contains an anion exchange resin comprising a cross- linked polymer containing a monomer of the formula (X- is a counter ion) and other monomers (e.g. ethylene, propylene, styrene, methyl methacrylate) as constituents. The ion exchange resin is obtained by copolymerizing chloromethyl styrene, the monomer of the formula, a copolymerizable monomer and a cross-linking agent (e.g. divinylbenzene, trivinylbenzene) and subsequently reacting the obtained water-insoluble cross-linked copolymer with pyridine. The monomer of the formula is introduced into the copolymer in an amount of 0-90mol.%, preferably 0-50mol.%, based on the whole monomers.;COPYRIGHT: (C)1995,JPO
机译:用途:制备包含离子交换树脂的胆汁酸吸附剂,该离子交换树脂包含特定的交联聚合物,剂量小,剂量低,口服时异物感降低,对酸具有较高的稳定性,可用作高脂血症治疗能够降低血液中胆固醇值的药物。 ;组成:该试剂包含阴离子交换树脂,该树脂包含交联聚合物,该交联聚合物包含式(X -是抗衡离子)的单体和其他单体(例如乙烯,丙烯,苯乙烯,甲基丙烯酸甲酯) )作为组成部分。通过使氯甲基苯乙烯,下式的单体,可共聚的单体和交联剂(例如二乙烯基苯,三乙烯基苯)共聚,然后使所得的水不溶性交联共聚物与吡啶反应,得到离子交换树脂。相对于全部单体,下式的单体以0-90mol。%,优选0-50mol。%的量引入共聚物中。版权所有:(C)1995,JPO

著录项

  • 公开/公告号JPH07277993A

    专利类型

  • 公开/公告日1995-10-24

    原文格式PDF

  • 申请/专利权人 SEKISUI CHEM CO LTD;

    申请/专利号JP19940064985

  • 发明设计人 HIRATA OSAMU;KOBAYASHI KAZUO;

    申请日1994-04-01

  • 分类号A61K31/785;

  • 国家 JP

  • 入库时间 2022-08-22 04:26:38

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