PROCESS FOR THE PREPARATION OF FURO (3,4-c) PYRIDINE DERIVATIVES IN NON-RACEMIC FORM.

摘要

The invention relates to a method for the preparation in non-racemic form of furo (3,4-c) pyridine derivatives of formula, (see FIG. 1) in which R3, R'3, R4 and R6 represent various substituents, the method comprising the resolution of a racemic mixture of one of the compounds of formulas: (see fig 2.3) in which R3, R'3, R4 and R6 are as defined above and R7 represents an acyl group comprising of 1 at 18 carbon atoms, by subjecting the selected compound to the action of an esterase capable of hydrolyzing the (+) or (-) enantiomer of said as a compound, then separating the hydrolyzed compound and the non-hydrolysed compound. The invention also relates to the enantiomers or mixtures of enantiomers thus obtained and their pharmaceutically acceptable salts.