A 3,5-DI-T-BUTYL-4-HYDROXYPHENYL-1,3,4-THYDIAZOL OR OXADIAZOL OR 3,5-DI-T-BUTYL ACETYRIC ACID INGREDIENT FOR THE PREPARATION OF PHARMACEUTICAL COMPOUNDS WITH ANTI-INFLAMMATORY EFFECT CONTAINING AS ACTIVE INGREDIENT -4-HYDROXYPHENYL-1,2,4-TIADIAZOL, OXADIAZOL OR TRIAZOL

摘要

The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.