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System for the nasal administration of cyanocobalamine (vitamin B12)
System for the nasal administration of cyanocobalamine (vitamin B12)
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机译:鼻钴蓝素(维生素B12)的鼻腔给药系统
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摘要
System for the nasal administration of cyanocobalamine (vitamin B12). The system comprises the use of a formulation, which may or may not be isotonic, of appropriate viscosity, which contains bioadhesives and is presented in the form of gels, lotions, ointments, creams, suspensions or powders, also including preservatives, absorption promoters, physical and chemical stabilizers, pH buffers, solvents and vehicles which are appropriate for or compatible with cyanocobalamine. In a typical composition according to the invention, each 100 ml contains 0.41 g of cyanocobalamine, 5 ml of 70% sorbitol, 2 ml of pantothenol, 0.20 g of methylparaben, 0.18 g of acetic acid, 0.15 g of sodium acetate, 2 g of methyl cellulose, 1.50 ml of glycerine, 1000 ml of water, sodium chloride, 20 ml of polyglycolized glyceride (HLB=14), 5 ml of polyglycolized glyceride (HLB = 3.5), 10 ml of polyglyceryl isostearate and 0.02 g of propylparabene. The marked contrast between the rate of absorption via the oral route and via the intranasal route in the invention can be seen in the figure. IMAGE
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