System nasal administration of cyanocobalamin (vitamin B12).

摘要

NASAL ADMINISTRATION SYSTEM cyanocobalamin (vitamin B12). The system involves the use of a formulation may be isotonic or not, VISCOSITY SUITABLE CONTAINING bioadhesive AND PRESENTED IN THE FORM OF gels, lotions, ointments, creams, suspensions or powders, also including conservators, absorption promoters , STABILIZING physicists and chemists, pH buffers, solvents and suitable vehicles or compatible with cyanocobalamin. In a typical composition according to the invention and 100 ml, PARTICIPATING cyanocobalamin, 0.41g.; Sorbitol 70 percent; 5 ML .; Pantothenol, 2 ML .; METILPAROBEN, 0.20g; ACETIC ACID, 0.18 g; SODIUM ACETATE 0.15g; Methylcellulose, 2 G; GLYCERIN, 1.50 ML .; SODIUM CHLORIDE, WATER, 1000 ML .; Polyglycolized glyceride (HLB = 14), 20 ML .; Polyglycolized glyceride (HLB = 3.5), 5 ML .; Polyglyceryl ISOESTEORATO, 10 ml., PROPILPREREBEN, 0.02 G. IN FIGURE IS OBSERVED THE DEFENDANT IN CONTRAST rate of absorption by oral route and intranasally of the invention.