METHOD FOR THE IMMUNO-ASSAY OF ANTITHROMBIN III ACTIVATED BY A GLYCOSAMINOGLYCAN, CORRESPONDING MONOCLONAL ANTIBODIES AND METHOD FOR PRODUCING THEM

摘要

the invention relates to a method for the determination of antithrombin iii (at iii) activated by a glycosaminoglycan sulfate or a sulfated oligosaccharide with the in vivo effect of at iii is similarthe heparin, a sandwich type immunoassay and solid phase, characterized in that it has: a monoclonal antibody which recognizes in less effectively.the at iii the at iii activated by sulfate or a sulfated glycosaminoglycan oligosaccharides with at iii activity similar to that of heparin.and a monoclonal antibody which recognizes no in solution and at iii (at iii) activated by one of the sulfated glycosaminoglycans or of such oligosaccharides in solutionit recognizes the at iii turn.