MANNOSE IN VITRO BINDING ASSAY AND USES THEREOF IN SPERM EVALUATION

摘要

The present disclosure relates to novel procedures for use in determining male fertility by determining the presence or absence of mannose binding residues on the surface of spermatozoa. The invention has particular applicability in clinical settings for the detection of male factor infertility in preparation for in vitro fertilization. A further novel aspect of the invention is the ability of physicians to conduct fertility diagnoses of male patients in an office setting, without the need for expensive equipment or animal handling. Examples disclosed herein demonstrate the utility of these processes in achieving improved reliability and correlation with mannose binding to sperm and fertilization.