Monoclonal Antibodies to Human MDRI Multiple Drug Resistant Gene Products, and Methods of Use Thereof (A MONOCLONAL ANTIBODY TO A HUMAN MDRI MULTIDRUG RESISTANCE GENE PRODUCT, AND USES)

摘要

(UIC2 mAb) specific for the extracellular domain of cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells (UIC2 hybridoma, ATCC Approval No. HB11207), which produces a monoclonal antibody And a UIC2 / A hybridoma with ATCC approval number HB11287)mdr1 /RTI DNA-transformed spleen cells derived from Balb / c mice immunized with winter 3T3 fibroblasts. The resulting UIC2 mAb and its fragments and recombinant derivatives can then be used for the detection and isolation of multiple drug resistant primate cells and human mdr1 gene products and for the reversal of multiple drug resistance of primate cells, including multiple drug human tumor cells.