GLUTAMIN AND ASPARGIC ACID DERIVATIVES WITH ANTIGASTRIC ACTIVITIES AND PROCEDURES FOR THEIR PRODUCTION.

摘要

Glutamic and aspartic acid derivatives having general formula (I), in which n is 1 or 2, R1 is a phenyl group mono- or di-substituted with chloro, methyl or nitro groups such that hydrogen or the nitro group may be present in positions (2 and 6) of the phenyl group and hydrogen, chloro or the methyl group may be present in positions (3 and 5), and in which R2 is a linear or branched alkyl chain or a cyclo-alkyl group containing from 5 to 9 carbon atoms, the stereochemistry at the chiral centre marked with an asterisk in formula (I) being DL or D, and their pharmaceutically acceptable salts, useful for the therapeutic treatment of conditions induced by hypergastrinaemia. The compounds of the invention in fact show powerful antigastrin ("little gastrin" or G-17) and antipentagastrin activities.