A manufacturing method for optically active 3 - hydroxy pyrrolidine derivatives.

摘要

PURPOSE:To economically and inexpensively obtain the title compound which is an intermediate for medicine by reacting a readily available optically active 4-halo-3-hydroxybutane derivative used as a raw material with a benzylamine derivative. CONSTITUTION:An optically active 4-halo-3-hydroxybutane derivative expressed by formula I (R1 is lower alkyl or phenyl which may have a substituent group; X is halogen; * is asymmetric carbon atom) and used as a raw material is reacted with a benzylamine derivative expressed by formula II (Q is phenyl which may have a substituent group) and preferably used at an amount of equivalent mol to two times by mol, preferably 1.1-1.2 times by mol based on the compound expressed by formula I, in a solvent such as methanol in the presence of an inorganic base such as sodium carbonate to provide the compound expressed by formula III. Furthermore, the compound expressed by formula I is obtained by reacting an optically active 4-halo-1,3-butanediol expressed by formula IV with a sulfonyl compound expressed by formula V.