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Substituted guanine nucleoside derivatives, immunoreaction-enhancing preparations thereof, process for enhancing an immune response, use of the derivatives for the preparation of a pharmaceutical composition and process for the preparation of substituted guanine nucleoside derivatives
Substituted guanine nucleoside derivatives, immunoreaction-enhancing preparations thereof, process for enhancing an immune response, use of the derivatives for the preparation of a pharmaceutical composition and process for the preparation of substituted guanine nucleoside derivatives
7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are =O, =S, =Se and =NCN. Compositions and methods of use are also disclosed.
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