Mac-1 i-domain protein useful in blocking adhesion and migration of neutrophils

摘要

An isolated and purified protein of the I-Domain from the human leukocyte beta 2-integrin Mac-1, expressed in recombinant Escherichia coli as a soluble fusion protein with glutathione S-transferase (GST). The protein, a functional derivative, fragment, analog or chemical derivative of such fragment is useful in the treatment of inflammation by interfering with the cell adhesion mechanism to block adhesion and migration of neutrophils.