Novel monoclonal antibody having inhibitory effect on type ii phospholipase a2 and protein containing a part of the same

摘要

A novel monoclonal antibody capable of inhibiting the activity of type II phospholipase A2 was obtained. Since said antibody is able to inhibit the activity of human type II phospholipase A2 as well as monkey type II phospholipase A2 and/or mouse type II phospholipase A2, it is not only clinically useful, but also usable as such in preclinical tests with the use of monkey or mouse. The antibody, which a completely novel property of releasing type II phospholipase A2 bound to the cell membrane, seems to strongly inhibit the activity of said enzyme via a novel mechanism. The monoclonal antibody or protein comprising a part thereof of the present invention can be used as therapeutics for cardiac infarction, cerebral infarction, etc. wherein type II phospholipase A2 is involved.