A RESIN FOR USE IN SOLID PHASE SYNTHESIS FOR THE PREPARATION OF PEPTIDE HYDRAZIDES

摘要

The present invention is directed to a handle for use on a solid phase resin for peptide synthesis. In particular, the invention relates to a 2-methoxy-4-alkoxy-benzyloxycarbonyl hydrazide handle to provide a useful resin for solid phase synthesis. The handle provides for Fmoc peptide synthesis, followed by cleavage of a side chain-protected petpide hydrazide under mild conditions. The invention further relates to side chain-protected peptide hydrazides, in which the protecting groups are those used in Fmoc synthesis.