Process for preparing (1R,5S,6S)-2-(6,7-dihydro-5H-pyrazolo1,2-a1,2,4triazolium-6-yl)thio-6-(R)-1-hydroxyethyl-1-methyl-carbapenem-3-carboxylate and starting materials thereof

摘要

Novel and improved simple process for preparing carbapenem compound, (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate represented by the following formula:;This compound may be prepared by using a mercapto reagent, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium derivative of the following formula:    wherein X^⊖ is an anion charge.