Process for preparing optically active N-tert-butyl-2-piperazinecarboxamide and its racemization process (PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE)

摘要

(R, S)-N-tert-butyl-2-piperazinecarboxamide was subjected to optical resolution using optically active lactic acid, optically active malic acid or optically active tartaric acid as a resolving agent to obtain optically active N-tert-Razine carboxyamide. Optically active N-tert-butyl-2-piperazinecarboxamide which is useful as a medicament intermediate or the like is obtained with high optical purity. Further, by optically cleaving the optically active N-tert-butyl-2-piperazinecarboxamide in the presence of a basic compound and performing optical resolution, an enantiomer which has remained as an unavailable enantiomer by the above optical resolution can be usefully used.