nitrogen containing diheterocycloheteroethanoanthracenderivate as antianxiety agents.

摘要

A class of ethanoanthracene derivatives is described having use in treatment of CNS disorders such as psychotic, convulsive and dystonic disorders. Compounds of particular interest are those of the formula CHEM wherein each of R5 and R6 is independently selected from hydrido, loweralkyl, benzyl and phenyl; wherein each of R7 through R11 is independently selected from hydrido, loweralkyl, hydroxy, benzyl, phenyl, loweralkoxy, phenoxy, benzyloxy, halo and haloloweralkyl; wherein R12 may be selected from hydrido, loweralkyl, cycloalkyl of five or six carbon atoms, cycloalkylalkyl of six or seven carbon atoms, phenyl, hydroxyloweralkyl, and heteroaryl selected from saturated or fully unsaturated heterocyclic rings containing five to seven ring members of which one or two ring members are nitrogen atom; wherein each Y is independently one or more groups selected from hydrido, hydroxy, loweralkyl, benzyl, phenyl, loweralkoxy, phenoxy, haloloweralkyl, halo, and loweralkanoyl; and wherein each of R13 through R20 is independently selected from hydrido, lower alkyl, benzyl, phenyl and halo; wherein R12 together with one of R13, R14, R19 or R20 may form a fused heterocyclic ring containing five or six ring members; or a pharmaceutically-acceptable salt thereof.