Inhibitors of N-myristoyl transferase, their method of preparation and the pharmaceutical compositions containing them.

摘要

Compounds of formula (I): …IMAGE… which can be used as N-myristoyltransferase inhibitors, in which … …  R1 represents a hydrogen atom, a substituted or unsubstituted (C1-C6) alkyl group, substituted or unsubstituted phenyl, (C3-C7) cycloalkylmethyl, substituted or unsubstituted (2-imidazolyl)methyl, substituted or unsubstituted (3-indolyl)methyl or (1-aza-2-indolizinyl)methyl, …  R2 and R3, which are identical or different, represent a hydrogen atom or a (C1-C6) alkyl group, or else, when R1 represents a hydrogen atom, R2 and R3 form, with the carbon and nitrogen atoms to which they are attached, a mono-, bi- or tricyclic heterocycle, …  X represents a -CO-, -SO2-, or -PO(OH)- group, …  Y represents a -COR5 or -POR6R6' group, …  R4 represents a linear or branched, substituted or unsubstituted (C6-C21) alkyl group in which, according to the case, one or more methylene groups can be replaced by an oxygen or sulphur atom or a p-phenylene nucleus, … their isomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or base. …??Medicaments.