New inhibitors n-myristoyl transferase, their preparation process and pharmaceutical compositions containing them.

摘要

The invention relates to compounds of formula (I): USED AS INHIBITORS OF N-myristoyltransferase, in which R SUB 1 is a hydrogen atom, an alkyl group (C SUB 1-C SUB 6) substituted or unsubstituted, substituted phenyl or unsubstituted cycloalkyl, (C 3-C SUB SUB 7) methyl, (IMIDAZOLI-2-YL) mETHYL substituted or unsubstituted, (INDOL-3-YL) mETHYL substituted or unsubstituted, (1 -ARAINDOLIZIN-2 -yl) methyl, R SUB 2, R SUB 3 identical or different, represent a hydrogen atom or an alkyl group (C 1-C SUB SUB 6), or when R SUB 1 is a hydrogen atom, R SUB 2 SUB YR 3 formed with carbon atoms and nitrogen which they are attached, a heterocycle mono-, bi- or tricyclic, X represents a group -CO-, -SO SUB 2-, -PO (OH) -, Y represents a SUB GROUP -COR 5 (C SUB SUB 6-C 21) alkyl, substituted or substituted phenyl wherein, as appropriate, one or more groups methylenes may be replaced by an oxygen atom, OR SULFUR NUCLEO P.FENILENO, its isomers, diastereoisomers and epimers as well as their addition salts with an acid or a pharmaceutically acceptable base. MEDICINES.