Novel Farnesyl Transferase Inhibitors, their Preparation and Pharmaceutical compositions containing them.

摘要

The new products of general formula (I) are summarized,Their preparation and pharmaceutical components containing them In general formula (I),Rrepresents: a radical of the general formula - (CH2) m-X1- (CH2) nZ, in which: X1 = single bond or O or S, m = 0 or 1, and n = 0, 1 or 2, the radicals CH2 they can be substituted by carboxy, alkoxy carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, amino, alkylamino, dialkylamino and Z represents: carboxy; COOR4, (R4 = alkyl) or: CON (R 5) (R6) (R5 = H or alkyl, R6 = H or optionally substituted alkyl, or R5 = H or alkyl, and R6 = hydroxy, optionally substituted alkyloxyethyl, or amino, or: PO (OR7) 2 (R7 = H or alkyl),o: A radical - nh-co-t / (t = h or an alternative)or: unradical -CH2N =;R1 and R2 = hydrogen or halogen or tar, finally replaced tar, or R1 and R2 in the same position respectively form a heterocycle composed of 1 or 2 heteroatoms and replaced by wind, or R1 = hydrogen or halogen or tar, new asphalt, and R2 = sulfur group; R3 = hydrogen or halogen or tar, acyl, tar, asphalt, anthrax or hydrocarbon; X3 = OS or NH -.-Co -, methylene, ethylene, asphalt or 1, 1, 1, 1, cyclopropyl, e = or S. new products of general formula (I);They are inhibitors of metastasis, and have obvious anti-tumor and anti leukemia properties.