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Method of down-regulating a gene linked to a P-53 responsive element
Method of down-regulating a gene linked to a P-53 responsive element
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机译:下调与P-53反应元件相关的基因的方法
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摘要
The present invention provides regulatory elements that are linked to genes involved in cell death and are regulated by p53 tumor suppressor protein. Examples of such p53 responsive elements (p53-RE) include p53-RE. sup.D, which is involved in p53-mediated down-regulation of the Bcl-2 gene, and p53-RE.sup.U, which is involved in p53-mediated up- regulation of the Bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death and contains a p53-RE.
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