STRUCTURES OF NUCLEIC ACIDS FOR CONTROLLED EXPRESSION OF GENES, CELLS CONTAINING SUCH STRUCTURES AND THEIR USE FOR PREPARING MEDICAMENTS

摘要

A new nucleic acid construct for cell-cycle regulated expression of at least one gene (I) comprises: (a) an activating sequence; (b) a promoter module including nucleotide sequences that separately bind members of the E2F and CHF protein families; and (c) (I), encoding an active agent. Also new are isolated cells containing the constructs.