Growth hormone releasing factor analogs their preparation and pharmaceutical compositions containing them

摘要

Novel growth hormone releasing factor analogs are presented having a sequence of twenty-nine to forty-four amino acids (SEQ ID NO: 6) wherein Xaa at position 1 is His, 3-MeHis, desNH2His, Tyr, or desNH2Tyr; Xaa at position 2 is Val, Leu, Ile, Ala, D-Ala, N-Methyl-D-Ala, Gly, Nle, or Nval; Xaa at position 8 is Gln, Ser, or Thr; Xaa at position 15 is Ala or Leu; Xaa at position 27 is Met, Nle or Leu; Xaa at position 28 is Ser or Asn; Xaa at position 29 is an amino acid residue sequence (SEQ ID NO: 7) or fragments thereof where the fragment is reduced in number by one to fifteen amino acid residues from the carboxyl-terminus, where the carboxyl terminus can be the free carboxylic acid or the corresponding amide, and the pharmaceutically acceptable acid or base addition salts thereof. The novel growth hormone releasing factor analogs have enhanced potency for the release of growth hormone and enzymatic stability, improved half-life stability in aqueous solution, and can be administered to a subject having a deficiency of growth hormone or for improvement of growth performance in livestock and other warm blooded animals and in fish and other cold blooded marine animals.