STABILISING SOLUTIONS OF DUOCARMYCIN DERIVATIVES BY ADDING SACCHARIDE, ELECTROLYTE, WATER-SOLUBLE POLYMER, POLYHYDRIC ALCOHOL AND/OR SURFACTANT

摘要

PCT No. PCT/JP95/00962 Sec. 371 Date Oct. 30, 1996 Sec. 102(e) Date Oct. 30, 1996 PCT Filed May 19, 1995 PCT Pub. No. WO95/31971 PCT Pub. Date Nov. 30, 1995Stabilized duocarmycin derivatives represented by formula (I): IMAGE (I) IMAGE wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electrolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.