process and 2 - (cyanoimino) - quinazlin intermediates for the manufacture of 6.7 - di (chloro) - 1.5 - di (hydro) - imidazo (2.1 - b amp; quinazolin - 2 (3h amp; on and process for presentation of 2 - (cyanoimino) quinazolin

摘要

A subject matter of the invention is a process for the preparation of 6,7-di-(chloro)-1,5-di-(hydro)-imidazo[2,1-b]quinazolin-2[3H]-one of formula CHEM or a salt thereof including their hydrates, characterized by subjecting [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl] -acetonitrile or a /2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl/ -acetic acid alkylester of the general formula CHEM wherein R' stands for a cyano group or a group of the formula CHEM in which latter R1 represents a straight or branched alkyl group having from 1 to 6 carbon atom(s), optionally carrying a phenyl substituent, to thermic cyclization in an acidic medium. Further subject matters of the invention are [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl] -acetonitriles or -acetic acid alkylesters of the general formula CHEM wherein R' is as defined above, useful as intermediates in the said process and a process for preparing them.